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Glaucoma Disease

A leading cause of blindness in the world, it is a progressive optic neuropathy often associated with increased intraocular pressure and characterized by progressive death of retinal ganglion cells (RGCs).1

Glaucoma is a common eye disease affecting millions of people around the world. It is a progressive condition where retinal ganglion cells (RGCs), the signalling cells in the back of the eye, begin to die.1 These cells join to form the optic nerve which links to the brain. Damage to these cells can cause changes in vision and even potentially lead to blindness.

The degeneration of RGCs, which leads to the visual loss in glaucoma, is usually attributed to abnormally raised pressure in the eye, called intraocular pressure (IOP).2 The reason for this rise in pressure is due to a build-up of the fluid that flows through the eye, often because the fluid can’t drain away as it should. This increased pressure causes damage to the retinal ganglion cells, causing these cells to die.

1. Nucci C, Tartaglione R, Cerulli A, Mancino R, Spanò A, Cavaliere F, et al. Int Rev Neurobiol 2007; 82: 397-406.
2. Guo L. Cordeiro MF. Prog Brain Res 2008; 173: 437-450.